Editorial Perspectives: will SARS-CoV-2 reset public health requirements in the water industry? Integrating lessons of the past and emerging research
新年英文祝福语大全Best wishes for the year to come! 恭贺新禧！ Good luck in the year ahead! 祝吉星高照！ May you come into a good fortune! 恭喜发财！ Live long
Editorial Perspectives: 2019 novel coronavirus (SARS-CoV-2): what is its fate in urban water cycle and how can the water research community respond?
In the field of the best 85 business schools in Europe, HEC Paris remains in second place behind LBS, while Insead, the international school based in Fontainebleau, France, climbs two places to third.
Nano and biosensors for detection of SARS-CoV-2: challenges and opportunities
Soft matter science and the COVID-19 pandemic
Carbon-based antiviral nanomaterials: graphene, C-dots, and fullerenes. A perspective
Ultraviolet-C and other methods of decontamination of filtering facepiece N-95 respirators during the COVID-19 pandemic
The performance was his worst so far this season, yet, frankly, it wasn't too dissimilar from those that preceded it. In his 20th NBA season, the 37-year-old Bryant has looked his age.
The Lord of the Rings trilogy. The amount of time before I need an oil change. My cell phone's battery charge. What do all of these things have in common? The
埃马纽埃尔马克龙(Emmanuel Macron)会得到德国总理安格拉默克尔(Angela Merkel)对欧元区预算的承诺吗？
Trends and targets in antiviral phototherapy
Among the year’s biggest surprises was the plunge in gasoline pries. Economists differed on the economic impact—money in the pockets of consumers offset by declines in exploration and drilling activity—but everyone agreed that it was bearish for small cars and hybrids. The combination of cheap gas and a steep sticker price made the Cadillac ELR the runaway winner of the most disliked car of the year award. Only 155 of the Volt-based $80,000 cars found buyers in November.
For: Oldman's seemingly effortless embodiment of the wartime leader has won almost universal
A new point-of-care test for the diagnosis of infectious diseases based on multiplex lateral flow immunoassays
Shanghai is the most popular destination for new job seekers, followed by Shenzhen, Guangzhou and Beijing. Provincial capitals cities in central and western regions are also among the top choices for the new graduates.
Novel biosensing methodologies for ultrasensitive detection of viruses
4. Manufacturing won't save the economy.
Anti-tumor, -viral, and -bacterial activities of polyoxometalates for realizing an inorganic drug
For newcomers, these changes provide fresh housing options. But for residents, they can spell displacement. The same is true for shops such as De Robertis Pasticceria and Caffe in the East Village, which just closed after a 110-year run. And next year, the Union Square Cafe will likely conclude its 30 years in Union Square.
ACE2 as a potential therapeutic target for pandemic COVID-19
In the past 12 months, more than 20 provinces have introduced policies to encourage students to start their own companies by allowing them to quit studying but keep their student status for two to eight years. However, many industry insiders insist that students complete their studies and work a few years first.
最佳迷你剧集/电影类编剧：D?V?蒂文森斯(D.V. DeVincentis)，《美国罪案故事：公诉辛普森》，“玛西亚，玛西亚，玛西亚” (The People v. O. J. Simpson: American Crime Story, "Marcia, Marcia, Marcia")
Diagnostic technologies for COVID-19: a review
Complying with the law may prove challenging, even if improvements ultimately reduce long-term costs. In addition, 2015 is the deadline for buildings to convert from No. 6 heating oil to No. 4 oil, which is less polluting.
从“高跟鞋门”到“金棕榈狗狗奖”（Palm Dog），再到迅速走红的“老爹身材（Dad bod）”，戛纳电影展的这12天，真是令人眼花缭乱。随着电影节进入尾声，英国广播公司回顾了本届戛纳影展上的九桩事。
Targeting severe acute respiratory syndrome-coronavirus (SARS-CoV-1) with structurally diverse inhibitors: a comprehensive review
Targeted poverty alleviation
*最佳真人秀主持：鲁保罗?查尔斯(RuPaul Charles)，《鲁保罗变装皇后秀》(RuPaul’s Drag Race, Logo)
An overview of key potential therapeutic strategies for combat in the COVID-19 battle
年度最佳合唱：埃里克·丘奇、杰森·阿尔丁、卢克布·莱恩《The Only Way I Know》
Potential repurposed SARS-CoV-2 (COVID-19) infection drugs
To Anita Eerland and Rolf Zwaan [THE NETHERLANDS] and Tulio Guadalupe [PERU, RUSSIA, and THE NETHERLANDS] for their study “Leaning to the Left Makes the Eiffel Tower Seem Smaller."
Nature as a treasure trove of potential anti-SARS-CoV drug leads: a structural/mechanistic rationale
In search for effective and definitive treatment of herpes simplex virus type 1 (HSV-1) infections
“Why do we keep getting so many record-warm years?” Dr. Schmidt asked in an interview. “It’s because the planet is warming. The basic issue is the long-term trend, and it is not going away.”
Antiviral drug discovery: broad-spectrum drugs from nature
Andrew Bargery, campus and schools engagement leader at PwC, says Teach First graduates stand out: “They have already worked in a professional envir-onment and have professional maturity and are good at building relationships.”
201110/156989.shtmlThe Victoria's Secret Fashion Show just taped, and this year's was one of the most elaborate ever.
Influenza neuraminidase: A druggable target for natural products
It was an incredible achievement for SpaceX. The first stage rocket of one of its Falcon 9 launchers, having successfully lofted cargo to the International Space Station, managed to turn itself around, bleed off the enormous kinetic energy it had acquired while its main engines were burning, fly back down to Earth and land vertically - with balletic precision - on a rather tiny looking robotic barge floating somewhere in the Atlantic.
Emerging investigators series: the source and fate of pandemic viruses in the urban water cycle
The role of biosensors in the detection of emerging infectious diseases
Quantitative determination of mechanical stability in the novel coronavirus spike protein
Wal-Mart U.S. president and CEO Bill Simon
Interaction of hydroxychloroquine with SARS-CoV2 functional proteins using all-atoms non-equilibrium alchemical simulations
7. 《出局：禁止接触》(Out 1: Noli Me Tangere)，导演：雅克·里维特(Jacques Rivette)。
An EMBA also boosts corporate careers. “The skills I acquired were key to my promotion,” said one graduate. A fifth are now chief executives, managing directors or board members three years after graduation. Average salaries were up 52 per cent from $114,000 before the programme to $175,000 five years later.
? President Obama declared a "major disaster" in New York and New Jersey. Flooding devastated the coast and more than 2.3 million lost power. The National Guard rescued hundreds from flooding in New Jersey. The governor, Chris Christie, a Republican, said the damage was "unthinkable". He praised the "outstanding" co-operation he had received from Obama.
MPLEx: a method for simultaneous pathogen inactivation and extraction of samples for multi-omics profiling
Phil Baty, editor of the rankings, said: "it seems that China's relentless march up the global league tables has stalled, after making major gains in recent years. This new data shows just how hard it is for emerging powers to break into the traditional global elite."
No.2: Another Reason for Staying in Bed
Multicolored silver nanoparticles for multiplexed disease diagnostics: distinguishing dengue, yellow fever, and Ebola viruses
A network of walking and biking trails leads to other lakeside neighborhoods and to downtown, which is about 15 minutes by bicycle and 10 by car. The Walker Art Center and other museums are nearby. Hockey and skating are popular on the lakes in winter; canoeing, swimming and fishing in the summer.
Some industries will likely pick up faster than others. Industries such as construction and manufacturing will probably begin to hire sooner. Retail, tourism, and hospitality, which depend entirely on consumer spending, will probably be among the last to recover.
Inhibition of SARS coronavirus helicase by bismuth complexes
Unveiling the molecular mechanism of SARS-CoV-2 main protease inhibition from 137 crystal structures using algebraic topology and deep learning
Stanford Graduate School of Business in California rises from fifth place in 2016 to second, a position it last held in 2014. The Wharton School of the University of Pennsylvania is in third place.
The latest commerce ministry figures do not include real estate purchases by individuals, many of whom exploit loopholes in China's capital control regime to obtain foreign currency. But the foreign exchange regulator has recently moved to close such loopholes, notably by tightening control of forex purchases by individuals, who are allowed to exchange $50,000 worth of renminbi for foreign currency each year.
A serological aptamer-assisted proximity ligation assay for COVID-19 diagnosis and seeking neutralizing aptamers
《狼厅》(Wolf Hall)，PBS，4月5日播出。这一季最引人注目的选角，《国土安全》(Homeland)的主演达米恩·刘易斯(Damian Lewis)将在该剧中饰演亨利八世，两获托尼奖的马克·里朗斯(Mark Rylance)将饰演托马斯·克伦威尔(Thomas Cromwell)，这部经典改编剧改编自希拉里·曼特尔(Hilary Mantel)的畅销历史小说。
Revealing the molecular mechanisms of proteolysis of SARS-CoV-2 Mpro by QM/MM computational methods
The molecular mechanism of the proteolysis reaction catalyzed by SARS-CoV-2 Mpro, one of the enzymes essential for the replication process of the virus responsible for the COVID-19 pandemic, is described using computational QM/MM methods.
Multi-targeting of functional cysteines in multiple conserved SARS-CoV-2 domains by clinically safe Zn-ejectors
By combining evolutionary and physico-chemical principles, previously unknown druggable Zn-sites in multiple conserved SARS-CoV-2 domains have been identified.
Computer-generated “synthetic contingency” plans at times of logistics and supply problems: scenarios for hydroxychloroquine and remdesivir
The government-sponsored students have signed an agreement that says they are required to reimburse the government if they do not return home after completing their studies, said Xiong Binqi, vice president of 21st Century Education Research Institute.
碧昂斯与妮琪·米娜(Nicki Minaj)，《完美》(Flawless, Remix)，Parkwood/Columbia
Engineered unnatural ubiquitin for optimal detection of deubiquitinating enzymes
7. “The Kindergarten Teacher” In his tough, weird knockout, the Israeli director Nadav Lapid spins the story of a teacher’s obsession with a child poet to create a savage portrait of fanaticism and its costs.
The programme is ranked second for career progress three years after graduation. Tiemba’s graduates number only about 250 so far, making them an elite group.— LaurentOrtmans
Mr Koepke warns that this could easily be upset by the Fed.
A Digital Protein Microarray for COVID-19 Cytokine Storm Monitoring
Accelerating the repurposing of FDA-approved drugs against coronavirus disease-19 (COVID-19)
A point-of-care selenium nanoparticle-based test for the combined detection of anti-SARS-CoV-2 IgM and IgG in human serum and blood
Assessing potential inhibitors of SARS-CoV-2 main protease from available drugs using free energy perturbation simulations
The End of the Road
The inactivation mechanism of chemical disinfection against SARS-CoV-2: from MD and DFT perspectives
8.A New iPhone
A report by human resources website Zhaopin released recently found that only 3.1 percent of students expecting to graduate in July said they will start their own business, down from 6.3 percent in 2015.
Antiviral agents against COVID-19: structure-based design of specific peptidomimetic inhibitors of SARS-CoV-2 main protease
Pharmacophore-based approaches in the rational repurposing technique for FDA approved drugs targeting SARS-CoV-2 Mpro
Amino acid interacting network in the receptor-binding domain of SARS-CoV-2 spike protein
从“高跟鞋门”到“金棕榈狗狗奖”（Palm Dog），再到迅速走红的“老爹身材（Dad bod）”，戛纳电影展的这12天，真是令人眼花缭乱。随着电影节进入尾声，英国广播公司回顾了本届戛纳影展上的九桩事。
Greener liquid-phase synthesis and the ACE inhibitory structure–activity relationship of an anti-SARS octapeptide
An investigation is continuing into how La La Land was wrongly named Best Picture rather than the triumphant Moonlight.
1. You became a LinkedIn superstar overnight。
Anti-inflammatory, antiallergic and COVID-19 protease inhibitory activities of phytochemicals from the Jordanian hawksbeard: identification, structure–activity relationships, molecular modeling and impact on its folk medicinal uses
The 2017 grads of Tsinghua University earn an average salary of 9,065 yuan per month, according to the survey released by xinchou.cn, an internet salary survey and report provider.
The biomaterial polyphosphate blocks stoichiometric binding of the SARS-CoV-2 S-protein to the cellular ACE2 receptor
As we pointed out earlier, we've long been able to restore hearing to the deaf, but restoring sight to the blind is a much more complicated matter. When people lose their sight, their retinas no longer send signals from their photoreceptors to their brains. To make an artificial eye, we'd need to understand how the retina processes those signals, and that's a code scientists just haven't been able to crack.
Ilimaquinone (marine sponge metabolite) as a novel inhibitor of SARS-CoV-2 key target proteins in comparison with suggested COVID-19 drugs: designing, docking and molecular dynamics simulation study
Analysts survey by Bloomberg expected a rise to 1.9 per cent in January.
Design and optimization of a subunit vaccine targeting COVID-19 molecular shreds using an immunoinformatics framework
4. Your co-worker blabbed。
Several coumarin derivatives and their Pd(II) complexes as potential inhibitors of the main protease of SARS-CoV-2, an in silico approach
Coumarin derivatives and their Pd(II)-complexes have shown a higher binding potential towards SARS-CoV-2 Mpro than chloroquine/cinanserin along with lower toxicity.
Carotane sesquiterpenes from Ferula vesceritensis: in silico analysis as SARS-CoV-2 binding inhibitors
Sesquiterpenes, 8α-anisate-dauc-4-ene-3,9-dione (webiol anisate) (1) and 10α-acetoxy-6α-benzoate-jaeschkeanadiol (2) as well as several analogues (3–12) were root extracted from Ferula vesceritensis.
Quinazoline-Schiff base conjugates: in silico study and ADMET predictions as multi-target inhibitors of coronavirus (SARS-CoV-2) proteins
Design of 2-phenylquinazolin-4(3H)one-trihydroxyphenyl Schiff base conjugates as COVID-19 therapy.
Automated multiplex nucleic acid tests for rapid detection of SARS-CoV-2, influenza A and B infection with direct reverse-transcription quantitative PCR (dirRT-qPCR) assay in a centrifugal microfluidic platform
In July, the government made the first stab at regulating internet finance when 10 agencies, including the central bank, the banking regulator and the securities regulator jointly issued guidelines that provide an official definition of “internet finance” and specify which agencies are responsible for regulating which types of internet financial institutions.
The cost of living the Australian dream has surged with Sydney and Melbourne among the five most expensive cities in the world, outstripping most European and US locations, according to an annual survey released on Monday.
Emma Thompson, a two-time winner for Howards End and Sense and Sensibility, famously keeps hers in the loo: “They look far too outré anywhere else. They’re great big, gold, shiny things.” She’s not alone – Susan Sarandon, Lionel Richie and Sean Connery all claim to keep their golden fellas alongside their bidets and baths.
A modular microarray imaging system for highly specific COVID-19 antibody testing
Beijing is banning Chinese tour groups from visiting South Korea, the latest retaliation against the planned Korean deployment of the US-built Thaad missile shield, according to two people with knowledge of the plans.
Meanwhile, villages within the city's boundaries will be overhauled and low-end manufacturers and logistics companies removed.
Development of a tablet PC-based portable device for colorimetric determination of assays including COVID-19 and other pathogenic microorganisms
Inhibition of SARS-CoV-2 main protease by phenolic compounds from Manilkara hexandra (Roxb.) Dubard assisted by metabolite profiling and in silico virtual screening
There is a salary gap of nearly 22 per cent between male and female graduates three years after they finished their courses, $90,000 compared to $73,000. That gap had been 17 per cent whenstudents first graduated, so thisdifference has widened over time(see chart).
Rapid prediction of possible inhibitors for SARS-CoV-2 main protease using docking and FPL simulations
A combination of Autodock Vina and FPL calculations suggested that periandrin V, penimocycline, cis-p-Coumaroylcorosolic acid, glycyrrhizin, and uralsaponin B are able to bind well to SARS-CoV-2 Mpro.
Curcumin to inhibit binding of spike glycoprotein to ACE2 receptors: computational modelling, simulations, and ADMET studies to explore curcuminoids against novel SARS-CoV-2 targets
A density functional theory study on silver and bis-silver complexes with lighter tetrylene: are silver and bis-silver carbenes candidates for SARS-CoV-2 inhibition? Insight from molecular docking simulation
The Wizards need to surge ASAP if they want to stay in this. We saw what happened last year when they waited too long to get it together.
根据贝克?麦坚时国际律师事务所(Baker & McKenzie)和荣鼎咨询(Rhodium Group)的一份报告，2015年中国国有企业和民营企业在欧洲（包括挪威和瑞士，以及欧盟）总共投资了230亿美元，创历史新高；在美国投资了150亿美元。
An in silico perception for newly isolated flavonoids from peach fruit as privileged avenue for a countermeasure outbreak of COVID-19
3′-Hydroxy-4′-methoxy-chroman-7-O-β-D-glucopyranoside 4, together with three known compounds, ferulic acid heptyl ester 1, naringenin 2, and 4,2′,4′-trihydroxy-6′-methoxychalcone-4′-O-β-D-glucopyranoside 3, was isolated from peach fruits.
Understanding the role of galectin inhibitors as potential candidates for SARS-CoV-2 spike protein: in silico studies
The report also showed regions with a better-developed economy produce more cyberstars, with Beijing, Shanghai, Guangdong, Jiangsu and Zhejiang leading the rankings.
Characterization of a commercially-available, low-pressure UV lamp as a disinfection system for decontamination of common nosocomial pathogens on N95 filtering facepiece respirator (FFR) material
‘Our hope is that the Worst Passwords of the Year list will cause people to take steps to protect themselves online.’
A facile assay for rapid detection of COVID-19 antibodies
Potential role of medicinal plants and their constituents in the mitigation of SARS-CoV-2: identifying related therapeutic targets using network pharmacology and molecular docking analyses
Imports grew 6.7 per cent year-on-year to $152.2bn after falling 1.4 per cent the previous month, according to China’s General Administration of Customs, defying a median forecast predicting contraction would worsen to 1.9 per cent.
Remdesivir-bound and ligand-free simulations reveal the probable mechanism of inhibiting the RNA dependent RNA polymerase of severe acute respiratory syndrome coronavirus 2
Consensus virtual screening of dark chemical matter and food chemicals uncover potential inhibitors of SARS-CoV-2 main protease
“We sincerely apologize to Moonlight, La La Land, Warren Beatty, Faye Dunaway, and Oscar viewers for the error that was made during the award announcement for Best Picture. The presenters had mistakenly been given the wrong category envelope and when discovered, was immediately corrected.”
"Based on experience from previous years, the number of applicants could sharply increase as the application window closes, especially during the last three days of application," an unidentified official with the Ministry of Human Resource and Social Security said on the ministry's website.
Clinical decision support tool and rapid point-of-care platform for determining disease severity in patients with COVID-19
2. Google Docs
Apple Inc., Alphabet Inc.'s Google, and Coca-Cola Co. topped the list of the world's 100 most valuable brands in 2016, while technology and automotive brands dominated the overall rankings, according to a new report from brand consultancy Interbrand.
Whole-genome sequence analysis and homology modelling of the main protease and non-structural protein 3 of SARS-CoV-2 reveal an aza-peptide and a lead inhibitor with possible antiviral properties
The Atlanta-based group expects sales, adjusted for acquisitions, divestitures and currency fluctuations, to rise 3 per cent, compared with its earlier forecast of between 4 per cent and 5 per cent.
10. "Arrow" (2.2 million)
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease
Molecular docking reveals the potential of Salvadora persica flavonoids to inhibit COVID-19 virus main protease.
Smartphone-based multiplex 30-minute nucleic acid test of live virus from nasal swab extract
Anti-HIV drug repurposing against SARS-CoV-2
5. Confirmation of the discovery of a nearby habitable planet
"Even though these two researchers worked independently of one another, the combination of Shapley's basic theory and Roth's empirical investigations, experiments and practical design has generated a flourishing field of research and improved the performance of many markets," the academy said.
Length-scale dependence of protein hydration-shell density
Beauty and Evolution
High antiviral activity of mercaptoethane sulfonate functionalized Te/BSA nanostars against arterivirus and coronavirus
Aoki-san is a pleasure to work withon storyboard. With Aoki-san on the team it feels like a sure thing. The visionof these animations will be perfect.
A handheld continuous-flow real-time fluorescence qPCR system with a PVC microreactor
Police, who raided the criminal operation, said they also found beef tripe, cartilage and other out-of-date animal organs - all of which had been smuggled across the border from neighbouring Vietnam. In total 20 tonnes of illegal meat was seized.
About this collection
Given a choice, Chinese university graduates prefer to find employment rather than start a company.
导演贝尼特·米勒(Bennett Miller)认为卡瑞尔是饰演杜邦的合适人选，但不想让观众一眼就认出他来。他要求造型师比尔·科森(Bill Corso)改变卡瑞尔的外貌。